![]() OI type II is the most severe of the collagen types. OI type I is the most common and the mildest form of the disorder. It is found in bones, tendons and ligaments. ![]() These genes code for type 1 collagen, the most abundant collagen in the human body. These types account for 85-90 percent of OI cases and are caused by mutations (changes) in the COL1A1 or COL1A2 genes. OI may be a mild disorder or result in severe complications.įour main types of OI (the collagen types) have been identified based on clinical features and severity. The severity of OI also varies greatly, even among individuals in the same family. The specific symptoms and physical findings associated with OI vary greatly from person to person. The abnormal growth of bones is often referred to as a bone dysplasia. Osteogenesis imperfecta (OI) is a rare disease affecting the connective tissue and is characterized by extremely fragile bones that break or fracture easily (brittle bones). 5 Myths About Orphan Drugs and the Orphan Drug Act.Information on Clinical Trials and Research Studies.
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